Off-label indications or uses for Fluoxetine

An off-label indication or off-label drug use is when a doctor prescribes a medication for a treatment that still hasn’t been officially approved by the FDA (U.S. Food and Drug Administration). This means that a drug is being prescribed for a different use than the ones labeled to the FDA by the drug manufacturer.

In this blog post we’re going to write about the off-label uses for Fluoxetine, commonly known as Prozac, a drug that works affecting the communication between nerve cells in the Central Nervous System (CNS) and restoring the chemical balance in the brain. Fluoxetine is used for the treatment of some types of disorders, such as: depressive disorder, bulimia, obsessive-compulsive disorder (OCD) and panic disorder.

Off-label indications or uses for Fluoxetine

Fluoxetine antidepressant drug


Fibromyalgia: Fibromyalgia is a chronic musculoskeletal disorder characterized by widespread pain and tenderness and Fluoxetine helps decreasing the severity of pain.

Migraine: Fluoxetine can helps to reduce the severity of pain in patients with migraine who takes Fluoxetine for at least 3 months

Hot Flashes caused by hormonal chemotherapy: Fluoxetine helps to alleviate menopause symptoms such as hot flashes in a short term use

Raynaud’s phenomenon: Some studies shows that Fluoxetine reduces the attack frequency in patients with Raynaud’s phenomenon.

With MatchMyRx patients and providers can match medications with medical conditions to identify off-label indications or drug uses.